Darien Gap between Panama and Colombia. The Darien gap is the most difficult part of travelling the Americas. If the Pan American Highway is completed it would be possible to drive from North America to Argentina in South America. Between Panama and Colombia, the Darien Gap is a stretch of about 50 miles where there is no road. To cross it involves a sharp machete, a strong arm, good mosquito repellent, malaria prophylactic, food, and lots of patience. Also, timing must be in the dry season. Since the early '90s, crossing the Darien on foot is considered by most locals as dangerous since it has recently become a channel for drug smugglers from Colombia. For most normal people, including those only slightly abnormal, this leaves three options. Fly, take a boat, or turn around.